Amlodipine mesylate
- Product NameAmlodipine mesylate
- CAS246852-12-0
- CBNumberCB11106917
- MFC20H25ClN2O5.CH4O3S
- MW0
- MDL NumberMFCD02682959
- MOL File246852-12-0.mol
- MSDS FileSDS
Amlodipine mesylate Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| Biosynth WJA85212 | 50mg | $900 | 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate |
Buy |
| Biosynth WJA85212 | 500mg | $900 | 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate |
Buy |
| Biosynth WJA85212 | 25mg | $900 | 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate |
Buy |
| Biosynth WJA85212 | 250mg | $900 | 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate |
Buy |
| Biosynth WJA85212 | 100mg | $900 | 3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate methanesulfonate |
Buy |
Amlodipine mesylate Chemical Properties,Usage,Production
Uses
Amlodipine mesylate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine mesylate can be used for the research of high blood pressure and cancer[1][2][3].in vivo
Amlodipine mesylate (5 mg/kg/day; s.c. for 2 weeks) significantly decreases systolic blood pressure (SBP) in VSMC ATP2B1 KO mice[4].
Amlodipine mesylate (10 mg/kg; i.p. once daily for 20 days) causes a significant retardation of tumor growth and prolongs the survival of A431 tumor-bearing mice[3].
| Animal Model: | ATP2B1loxP/loxP mice[4] |
| Dosage: | 5 mg/kg/day |
| Administration: | Subcutaneously implanted osmotic pump for 2 weeks |
| Result: | Significantly decreased the blood pressure. |
IC 50
L-type calcium channelReferences
[1] Kishen G. Bulsara, et al. Amlodipine.[2] Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586. DOI:10.2165/00003495-199550030-00009
[3] Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12. DOI:10.1016/j.ejphar.2004.04.006
[4] Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87. DOI:10.1038/hr.2017.92
Preparation Products And Raw materials
Amlodipine mesylate Supplier
Global(34)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 | |
| +86-29-81139210 +86-17392587031 |
1059@dideu.com | China | 9983 | 58 | |
| +86-0551-65418684 +86-18949823763 |
sales@tnjchem.com | China | 25333 | 58 | |
| +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49709 | 58 | |
| 13564774135 | marketing@targetmol.com | United States | 19950 | 58 | |
| 15527621225; 15527621225 |
1791901229@qq.com | China | 6746 | 52 | |
| 0731-85526065 13308475853 |
ivy@hnhbsj.com | China | 7236 | 62 | |
| 021-64609169 18901607656 |
greensnown@163.com | China | 9883 | 50 | |
| sales@njromanme.com | China | 4511 | 58 | ||
| 025-58859352 17714375163 |
qzhang@aikonchem.com | China | 15525 | 58 |
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