Description
Sulfamethizole-d
4 is intended for use as an internal standard for the quantification of sulfamethizole by GC- or LC-MS. Sulfamethizole is a broad-spectrum sulfonamide antibiotic (MIC
90s = 1.25-5,000 μg/ml against clinical isolates of
E. coli and
K. pneumoniae).
1 It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.
References
1. Wambaugh, M.A., Shakya, V.P.S., Lewis, A.J., et al.
High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance PLoS Biol. 15(6):e2001644,(2017).
