2470130-12-0

Sulfamethizole-d₄ is intended for use as an internal standard for the quantification of sulfamethizole by GC- or LC-MS. Sulfamethizole is a broad-spectrum sulfonamide antibiotic (MIC₉₀s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae).¹ It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.

Sulfamethizole-d4-1 is the deuterium labeled Sulfamethizole[1]. Sulfamethizole is a sulfathiazole antibacterial agent[2][3].

1. Wambaugh, M.A., Shakya, V.P.S., Lewis, A.J., et al. High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance PLoS Biol. 15(6):e2001644,(2017).