Biological Activity
Sartorypyrone D is a fungal metabolite that has been found in N. fischeri.1 It inhibits NADH fumarate reductase (NFRD; IC50 = 1.7 μM in A. suum mitochondria) and NADH oxidase (IC50 = 3 μM in bovine heart mitochondria). Sartorypyrone is active against the Gram-positive bacteria B. subtilis, K. rhizophila, and M. smegmatis in disc assays.
References
1.Kaifuchi, S., Mori, M., Nonaka, K., et al.Sartorypyrone D: A new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897J. Antibiot. (Tokyo)68(6)403-405(2015)
