Description
α-Muricholic acid-d4 is intended for use as an internal standard for the quantification of α-muricholic acid (Item No. 20291) by GC- or LC-MS. α-Muricholic acid is a murine-specific primary bile acid.1,2 Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity, which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids.3 Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.4WARNING This product is not for human or veterinary use.
References
[1] HENDRIK J. EYSSEN Jan A M Guido G PARMENTIER. Sulfated Bile Acids in Germ-Free and Conventional Mice[J]. The FEBS journal, 1976, 66 3: 507-514. DOI:
10.1111/j.1432-1033.1976.tb10576.x[2] TETSUYA UEHARA. c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation.[J]. Transplantation, 2004, 78 3: 324-332. DOI:
10.1097/01.tp.0000128859.42696.28[3] KEITA WATANABE. Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids.[J]. ACS Applied Bio Materials, 2018: e0202083. DOI:
10.1371/journal.pone.0202083[4] MICHAEL R. LA FRANO . Diet-induced obesity and weight loss alter bile acid concentrations and bile acid–sensitive gene expression in insulin target tissues of C57BL/6J mice[J]. Nutrition Research, 2017, 46: Pages 11-21. DOI:
10.1016/j.nutres.2017.07.006
