(1R,1'R,2S,2'S)-DUANPHOS

Reactions

1. As a highly electron-donating and conformationally rigid ligand, the rhodium complex of DuanPhos has exhibited remarkably high enantioselectivities and reactivities for the hydrogenation of a variety of functionalized olefins.
2. Rhodium/DUANPHOS catalyst used in the synthesis of 2-trifluoromethyl lactic acid by asymmetric hydroformylation.

Uses

• Stereoselective synthesis of cyano-substituted dihydropyrroles by annulation of cyanoallenes
• Rhodium-catalyzed intermolecular enantioselective hydroacylation of alkynes to give alpha- and beta-substituted unsaturated ketones by kinetic resolution
• Stereoselective preparation of β-amino nitriles via rhodium-catalyzed asymmetric hydrogenation of amino acrylonitriles
• Stereoselective preparation of anti-1,3-amino alcohols via rhodium-catalyzed asymmetric hydrogenation of β-ketoenamide intermediates
• Stereoselective preparation of acetylaminoindane via rhodium-catalyzed asymmetric hydrogenation of acetylaminoindene

General Description