Originator
Butetamat-dihydrogencitrat,Chemische Werke
Hommel GmbH
and Co.KG
Definition
ChEBI: Butetamate is an alkylbenzene.
Manufacturing Process
16.4 parts of alpha-phenylbutiric acid, 17.5 parts of beta-diethylaminoethylchloride hydrochloride and 35 parts of dry potassium
carbonate in 60 parts diisopropyl ether was stirred for 18 hours under reflux.
To the reaction mixture at 40°C was added 120 parts of the water. Organic
layer was washed with the water. The solvent was removed and the 2-
(diethylamino)ethyl-2-phenylbutyrate was distilled at 167-168°C/10 mm;
melting point of hydrochloride 167-169°C.
In practice it is usually used as citrate.
Therapeutic Function
Anticholinergic, Spasmolytic, Antitussive
