Uses
Retelliptine (BD84), a derivative of ellipticine, is an inhibitor of Topoisomerase II with anticancer activity. Retelliptine can bind to DNA and inhibit Topoisomerase II during DNA replication[1][2].
References
[1] Kattan J, et al. Phase I study of retelliptine dihydrochloride (SR 95325 B) using a single two-hour intravenous infusion schedule[J]. American journal of clinical oncology, 1994, 17(3): 242-245. DOI:
10.1097/00000421-199406000-00013[2] Maulard C, et al. Binding of retelliptine, a new antitumoral agent, to serum proteins and erythrocytes[J]. Biochemical pharmacology, 1990, 40(4): 895-898. DOI:
10.1016/0006-2952(90)90333-g