Description
GSK-5503A is a novel selective CRAC channel blocker.
Uses
GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker. GSK-5503A effectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. GSK-5503A can be used for the research of asthma and allergic disorders[1].
References
[1] Derler I, et al. The action of selective CRAC channel blockers is affected by the Orai pore geometry. Cell Calcium. 2013 Feb;53(2):139-51. DOI:
10.1016/j.ceca.2012.11.005