Nalmefene hydrochloride

Product NameNalmefene hydrochloride

CAS58895-64-0

CBNumberCB0855103

MFC21H25NO3.ClH

MW375.89

EINECS232-572-4

MDL NumberMFCD27937056

MOL File58895-64-0.mol

Chemical Properties

Melting point	180-185°
storage temp.	Desiccate at RT
solubility	Soluble in Water (up to 25 mg/ml).
form	solid
pka	7.63(at 25℃)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
CAS DataBase Reference	58895-64-0

Nalmefene hydrochloride Price

Product number	Packaging	Price	Buy
Tocris 4085	50	$118	Buy
American Custom Chemicals Corporation API0009358	1MG	$400.43	Buy
American Custom Chemicals Corporation API0009358	5MG	$402.75	Buy
American Custom Chemicals Corporation API0009358	10MG	$404.35	Buy
Crysdot CD31001381	250mg	$160	Buy

Nalmefene hydrochloride Chemical Properties,Usage,Production

Description
Nalmefene hydrochloride has been introduced in the U.S.A. for opioid reversal following surgery, and in the reversal of opioid overdoses and epidurally administered narcotics. Nalmefene is an opioid antagonist that inhibits respiratory, analgesic and subjective effects of opioids. It has a higher potency, a longer duration of action, and superior bioavailability than the structurally related naltrexone. Nalmefene has a wide spectrum of biological activity and is in clinical trials for the treatment of interstitial cystitis, recalcitrant pruritus of cholestasis, stroke, rheumatoid arthritis, shock, CNS trauma, and alcoholism. Studies indicate that nalmefene does not induce morphine-like effects and has no apparent abuse potential.
Originator
IVAX (U.S.A.)
Uses
Nalmefene Hydrochloride is a structural analog of Naltrexone (N285780) with opiate antagonist activity used in pharmaceutical treatment of alcoholism. Other pharmacological applications of this compound aim to reduce food cravings, drug abuse and pulmonary disease in affected individuals. Used as an opioid-induced tranquilizer on large animals in the veterinary industry. Narcotic antagonist
brand name
Revex
References
1) Osborn et al. (2010), In vivo characterization of the opioid antagonist nalmefene in mice; Life Sci., 86 624 2) Butelman et al. (2009), Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in non-human primates: fast onset and entry in cerebrospinal fluid; J. Pharmacol. Exp. Ther., 328 588 3) Butelman et al. (2008), The effects of herkinorin, the first mu-selective ligand from salvinorin A-derived scaffold, in neuroendocrine biomarker assay in nonhuman primates; J. Pharmacol. Exp. Ther., 327 154 4) Soyka and Rosner (2008), Opioid antagonists for pharmacological treatment of alcohol dependence – a critical review; Curr. Drug Abuse Rev., 1 280

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