ChemicalBook CAS DataBase List 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-

Product Name2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-
CAS2226664-93-1
CBNumberCB08094272
MFC17H11Cl2N3O2
MW360.19
EINECS206-696-4
MOL File2226664-93-1.mol
MSDS FileSDS

Chemical Properties

Density	1.58±0.1 g/cm3(Predicted)
solubility	DMSO: Soluble
pka	8.80±0.20(Predicted)
form	Solid
color	Brown to reddish brown
InChI	InChI=1S/C17H11Cl2N3O2/c1-24-22-15-8-4-2-3-5-12(8)20-16(15)14-9-6-10(18)11(19)7-13(9)21-17(14)23/h2-7,20H,1H3,(H,21,23)
InChIKey	PROTUMHDKVZVBW-UHFFFAOYSA-N
SMILES	N1C2=C(C=C(Cl)C(Cl)=C2)C(=C2C(=NOC)C3=C(N2)C=CC=C3)C1=O

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 37579	1mg	$65	KY 19382 ≥95%	Buy
Cayman Chemical 37579	5mg	$260	KY 19382 ≥95%	Buy
Cayman Chemical 37579	10mg	$423	KY 19382 ≥95%	Buy
Biosynth BPD66493	1mg	$250	KY19382	Buy
Biosynth BPD66493	5mg	$337.5	KY19382	Buy

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Chemical Properties,Usage,Production

Uses

KY 19382 is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β.

in vivo

KY19382 (0.1 mg/kg; i.p. once daily for 2 weeks) delays growth plate senescence in older mice and promotes growth plate maturation in rapidly growing young mice^[1].
KY19382 (0.1 mg/kg; i.p. once daily for 10 weeks) significantly increases the length of tibiae in mice^[1].
KY19382 (5 mg/kg; i.p.) displays a relatively favorable bioavailability (F=16.74%), showing half-life of 16.20 h and an exposure level of 6,555.79 ngh/ml^[1].
KY19382 (A3051) (25 mg/kg; p.o. once daily for 16 weeks) shows reduction in adipocyte size and anti-inflammatory effects^[2].
A3051 (25 mg/kg; p.o. once daily for 5 days) reduces fasting glucose in mice^[2].
A3051 (25 mg/kg; p.o. once daily for 3 weeks) reduces the hepatosteatosis in mice^[2].

Animal Model:	C57BL/6 male mice (7-weeks-old or 3-weeks-old)^[1]
Dosage:	0.1 mg/kg
Administration:	I.p. once daily for 2 weeks
Result:	Increased nuclear β-catenin in the growth plate chondrocytes dramatically. Elevated the height of each growth plate zone and BrdU-positive cells. Did not affect the cartilage resorption of rapidly growing young mice.

Animal Model:	SD male rats^[1]
Dosage:	1 mg/kg for i.v. and 5 mg/kg for i.p. (Pharmacokinetic Analysis)
Administration:	I.v. and i.p. administration
Result:	I.v.: t_1/2=3.33 h; AUC=7832.81 ngh/mL; CL=0.12 L/h/kg. I.p.: t_1/2=16.20 h; F=16.74%; C_max=463.37 ng/mL.

IC 50

CXXC5-DVL: 19 nM (IC₅₀); GSK3β: 10 nM (IC₅₀)

References

[1] SEHEE CHOI. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.[J]. Life Science Alliance, 2019. DOI: 10.26508/lsa.201800254

Preparation Products And Raw materials

2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3961	58
Shaanxi Dideu Medichem Co. Ltd	+86-17392712779	1097@dideu.com	China	3989	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3374	58
Dingwang Technology (Wuhan) Co., Ltd.	+undefined-27-2786652399 +undefined13627115097	market02@senwayer.com	China	886	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Dideu Industries Group Limited	+8617392712697	1022@dideu.com	China	29095	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6378	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +86-15965530500	nickzhang@hangyubiotech.com	China	9935	58

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2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro- Spectrum

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