Description
KY19334 is a small molecule that activates the Wnt/β-catenin pathway by inhibiting the CXXC5–Dvl interaction and accelerates wound healing in diabetic mice. By restoring the suppressed Wnt/β-catenin signaling and thereby inducing the expression of its target genes, KY19334 enhances the wound-healing capacity of diabetic mice. Furthermore, KY19334 induces angiogenesis in mice with hindlimb ischemia.
References
[1] SEHEE CHOI. CXXC5 mediates growth plate senescence and is a target for enhancement of longitudinal bone growth.[J]. Life Science Alliance, 2019. DOI:
10.26508/lsa.201800254[2] Yoon, Minguen, et al. “KY19382 Accelerates Cutaneous Wound Healing via Activation of the Wnt/β-Catenin Signaling Pathway.”
International Journal of Molecular Sciences, 24 14, 2023,
https://doi.org/10.3390/ijms241411742.
[3] Ryu, Yeong Chan, et al. “KY19382, a Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis.”
British Journal of Pharmacology, 178 12, 2021, pp. 2533–46,
https://doi.org/10.1111/bph.15438.
[4] Lee, Soung-Hoon, et al. “Novel Small Molecules Downregulate CDK1 Expression and Inhibit Wnt/β-Catenin Signaling in Cutaneous Squamous Cell Carcinoma by Targeting Its Distinct Tumor-Specific Cellular Landscape.”
Experimental and Molecular Medicine, 57 9, 2025, pp. 1996–2009,
https://doi.org/10.1038/s12276-025-01532-y.
