Saikosaponin A (1-10 mg/kg, i.p, 7 d) attenuates the morphological changes in the small intestine induced by 5-FU[2].
Saikosaponin-A (1-10 mg/kg, i.p, 7 d) enhances the decrease of antioxidant enzymes in intestinal tissue caused by 5-FU[2].
| Animal Model: | 5-FU (HY-90006)-induced mucositis in BALB/c mice modle[2] |
| Dosage: | 1, 5, 10mg/kg/day, 7 d |
| Administration: | injected intraperitoneally (i.p) |
| Result: | Reduced villus blunting, crypt cells apoptosis, and inflammatory cell infiltration.
Decreased concentration of GSH, GST, Catalase, and SOD in intestinal tissue.
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