Description
15(S)-
HETE is a major arachidonic acid metabolite from the 15-
lipoxygenase pathway. In mammals, 15(S)-
HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-
HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.
Uses
15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity.
Uses
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.
Definition
ChEBI: An optically active form of 15-HETE having 15(S)-configuration..
General Description
15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).
Biochem/physiol Actions
Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.
