Big endothelin-1 (1-31) (human, bovine)
- Product NameBig endothelin-1 (1-31) (human, bovine)
- CAS133972-52-8
- CBNumberCB0690733
- MFC162H236N38O47S5
- MW3628.16
- MDL NumberMFCD01866298
- MOL File133972-52-8.mol
Chemical Properties
| storage temp. | -15°C |
| Sequence | Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr (Disulfide bridge:Cys1-Cys15;Cys3-Cys11) |
Big endothelin-1 (1-31) (human, bovine) Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| Biosynth PED-4360-S | 0.1mg | $816.7 | Endothelin-1 (1-31) (Human) |
Buy |
| Biosynth FB109624 | 50ug | $900 | Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt ) |
Buy |
| Biosynth FB109624 | 100ug | $900 | Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt ) |
Buy |
| Biosynth FB109624 | 25ug | $900 | Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt ) |
Buy |
| Biosynth FB109624 | 250ug | $1622.5 | Big Endothelin-1 (1-31) (human, bovine) trifluoroacetate salt ) |
Buy |
Big endothelin-1 (1-31) (human, bovine) Chemical Properties,Usage,Production
Uses
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase[1].in vivo
ET-1 (1-31) (100 nM; single dose) induces contraction in the mouse mesenteric artery. The contraction may be mediated by the ETA receptor and may be increased by aging. A clear difference exists between males and females in the present chronic diabetic condition[1].
| Animal Model: | ICR mice, Streptozocin (HY-13753)-induced diabetic model[1] |
| Dosage: | 100 nM |
| Administration: | In the organ bath, single dose |
| Result: | In the 1-week control (but not diabetic) group, induced contraction and the contractile response was significantly greater in female mice than in male mice, and there was no significant difference in either male or female mice between the age-matched controls and the diabetic mice. In the 8-weeks group, the contraction was or tended to be increased compared with the corresponding 1-week group in all mice. Although in male mice this contraction was not different between control and diabetic groups, it was significantly greater in diabetic female mice than in the control female mice and in female diabetic mice than in male diabetic mice. The contraction was inhibited by ETA receptor inhibitor. |
References
[1] Matsumoto T, et al. Gender differences in vascular reactivity to endothelin-1 (1-31) in mesenteric arteries from diabetic mice. Peptides. 2008 Aug;29(8):1338-46. DOI:10.1016/j.peptides.2008.04.001[2] Yoshizumi M, et al. Effect of endothelin-1 (1-31) on human mesangial cell proliferation. Jpn J Pharmacol. 2000 Oct;84(2):146-55. DOI:10.1254/jjp.84.146
Preparation Products And Raw materials
Big endothelin-1 (1-31) (human, bovine) Suppliers
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| 21-61263452 13641803416 |
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