Chemical Properties
Lyophilized
Uses
Concanavalin A is a plant lectin that is a T-cell mitogen, and induces apoptosis in human fibroblasts.
Uses
Concanavalin A is a unique lectin purified from the jack bean, C. ensiformis, that selectively cross-links cell-surface glycoproteins and affects the initiation of cell agglutination, mitogenesis, and apoptosis. Concanavalin A specifically binds to α-mannose and α-galactose structures found in sugars, glycoproteins, and glycolipids and has been used in affinity chromatography purifications of various glycoproteins and cellular structures. At 20 mg/kg concanavalin A is also used to induce liver injury in experimental mouse models of autoimmune hepatitis in order to study immune regulation by macrophages and T cells. Concanavalin A is toxic to several tumor cell lines and has been reported to induce programmed cell death of cortical neurons by a mechanism similar to that of the amyloid β peptide.
Uses
As a reagent in analytical and preparative biochemistry; as a probe in studies of cell surface membrane dynamics and cell division.
Definition
A lectin mitogen that binds specifically to and agglutinates transforms into tumors. It binds to glucose
and mannose residues in the surface.
General Description
Concanavalin A is a protein containing only β-sheets in its structure, and belongs to the legume lectins family.
Hazard
Poison; teratogen; mutagen.
Biochem/physiol Actions
Concanavalin A is known to stimulate acute hepatic inflammation and acts as a T‐cell mitogen. It has inhibitory effect on hepatocellular carcinoma by inducing autophagy.
