(S)-4,4-DIBUTYL-2,6-BIS(3,4,5-TRIFLUOROPHENYL)-4,5-DIHYDRO-3H-DINAPHTHO[7,6,1,2-CDE]AZEPINIUM BROMIDE

Reaction

1. 2nd Generation Maruoka chiral phase transfer catalyst, for enantioselective alkylation of α-amino acid derivatives, that is easily recovered for recycle by extraction with fluorous solvent.
2. Catalyst for asymmetric conjugate addition of α-substituted-α-cyanoacetates to α,β-unsaturated acetylenic esters.
3. Phase transfer catalyzed enantioselective α-alkylation.
4. Asymmetric amination of β-keto esters.
5. Diastereo- and enantioselective conjugate addition of α-substituted nitroacetates to maleimides.
6. Cyclization of β-alkynyl hydrazines.

Uses

(S)-4,4-Dibutyl-2,6-bis(3,4,5-trifluorophenyl)-4,5-dihydro-3H-dinaphtho[2,1-c:1'',2''-e]azepinium Bromide is a chiral phase-transfer catalyst for asymmetrical alkylation of glycine and alanine Schiff bases.