Uses
IWP-O1 is a highly potent Porcupine (Porcn) inhibitor, with an EC50 of 80 pM in L-Wnt-STF cells. IWP-O1 prevents the secretion of Wnt proteins. IWP-O1 suppresses the phosphorylation of Dvl2/3 and LRP6 in HeLa cells[1].
Biological Activity
IWP-O1 is a porcn inhibitor with an EC50 of 80 pM in a Wnt signaling reporter assay in cultured cells. It can effectively inhibit the phosphorylation of Dvl2/3 in Hela cells.
in vitro
IWP-O1 has good metabolic stability.
target
| Target | Value |
porcn
(Cell-based assay) | 80 pM(EC50) |
References
[1] You L, et al. Development of a triazole class of highly potent Porcn inhibitors. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895. DOI:
10.1016/j.bmcl.2016.11.012
