Description
This alkaloid has recently been shown to exhibit a marked antineoplastic activity.
Administration of 25 or 50 mg/kg intraperitoneally on alternate days or daily until
death to mice which had been inoculated with a single intraperitoneal dose of
106 -102 LI2l0 leukemia cells increased the survival time by 89-229 per cent
compared with control animals.
Japanese workers have recently reported the synthesis of olivacine by heating
indole with 4(1-hydroxyethyl)-3-methoxymethyl-2-methylpyridine in 47 per
cent HBr.
Definition
ChEBI: Olivacine is a member of carbazoles.
References
Regina et al., Cienc. Cult. (Sao Paulo), 26, 517 (1974)
Synthesis:
Kametani et al., J. Chern. Soc., Perkin I, 2102 (1975)
![1,5-DIMETHYL-6H-PYRIDO[4,3-B]CARBAZOLE Structure](https://www.chemicalbook.com/CAS/GIF/484-49-1.gif)
