Uses
Heparin is a polymer classified as a mucopolysaccharide or a glycosoaminoglycan. This product is biosynthesized and stored in mast cells of various mammalian tissues, particularly liver, lung, and mucosa. Commercial heparin is chiefly isolated from beef lung or pork intestinal mucosa. This product has been traditionally used as an anticoagulant. Heparin binds to antithrombin III, a naturally occurring plasma protease inhibitor, accelerating significantly the rate at which antithrombin III (AT-III) inhibits coagulation proteases (Factor Xa and thrombin).
References
[1] Purushothaman, Anurag, et al. "Fibronectin on the surface of myeloma cell-derived exosomes mediates exosome-cell interactions." Journal of Biological Chemistry 291.4 (2016): 1652-1663. DOI:
10.1074/jbc.M115.686295.
[2] Capila, Ishan, and Robert J. Linhardt. "Heparin–protein interactions." Angewandte Chemie International Edition 41.3 (2002): 390-412.
[3] Bj?rk, I., and U. Lindahl. "Mechanism of the anticoagulant action of heparin." Molecular and cellular biochemistry 48 (1982): 161-182. DOI:
10.1007/BF00421226.
[4] Le Brigand, H., et al. "Prevention of postoperative thrombo-embolic accidents following thoracic surgery by low-dose calcium heparinate: a comparative study (author's transl)." La Semaine des Hopitaux: Organe Fonde par L'association D'enseignement Medical des Hopitaux de Paris 57.19-20 (1981): 972-977.
[5] Beeler, D., R. Rosenberg, and R. Jordan. "Fractionation of low molecular weight heparin species and their interaction with antithrombin." Journal of Biological Chemistry 254.8 (1979): 2902-2913.
