Uses
4'-Methoxyflavone is a flavonoid with antioxidant properties and anti-proliferative activity against cancer cells. 4'-Methoxyflavone can inhibit cycle-dependent kinases leading to cell cycle arrest and regulate cell signaling pathways to influence cell proliferation and apoptosis. 4'-Methoxyflavone can be used in cancer chemoprevention research[1].
Definition
ChEBI: 2-(4-methoxyphenyl)-1-benzopyran-4-one is a member of flavonoids and an ether.
Biological Activity
4-methoxyflavone is a neuroprotective agent th at inhibits the accumulation of poly (ADP-ribose) and neuronal cell death following chemically-induced DNA damage or NMDA excitation.
References
[1] Walle U K, et al. Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones[J]. Drug Metabolism and Disposition, 2007, 35(11): 1985-1989. DOI:
10.1124/dmd.107.016782
