Description
Denopamine is a potent orally-active cardiotonic with selective effects on the beta,
adrenergic receptors. Unlike isoproterenol or dobutamine, denopamine’s positive
inotropic activity is not mediated through the release of catecholamines; its lack of effect
on heart rate and myocardial oxygen consumption thus offers significant advantages in the
management of congestive heart failure.
Originator
Tanabe Seiyaku (Japan)
Uses
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Definition
ChEBI: Denopamine is a dimethoxybenzene.
Biochem/physiol Actions
Denopamine is a cardiotonic drug.
