Description
Denopamine is a potent orally-active cardiotonic with selective effects on the beta,
adrenergic receptors. Unlike isoproterenol or dobutamine, denopamine’s positive
inotropic activity is not mediated through the release of catecholamines; its lack of effect
on heart rate and myocardial oxygen consumption thus offers significant advantages in the
management of congestive heart failure.
Chemical Properties
L-hydrochloride: C18H23NO4·HCl. Crystallizes from isopropanol, melting point 138-139.5°C. [α]
D23-38° (C=1, methanol). DL-hydrochloride: C18H23NO4·HCl. Crystallizes from isopropanol-isopropyl ether, melting point 164-167°C.
Originator
Tanabe Seiyaku (Japan)
Uses
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Definition
ChEBI: Denopamine is a dimethoxybenzene.
Biochem/physiol Actions
Denopamine is a cardiotonic drug.
