Pyridostatin hydrochloride

Biological Activity

Pyridostatin (RR82) hydrochloride is a highly selective G-quadruplex DNA stabilizer (Kd=490 nM). It promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage.

in vitro

Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest. It is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure.

target

storage

Desiccate at RT