FMoc-Val-Cit-PAB

Product NameFMoc-Val-Cit-PAB
CAS159858-22-7
CBNumberCB02730901
MFC33H39N5O6
MW601.69
MDL NumberMFCD22417106
MOL File159858-22-7.mol
MSDS FileSDS

Chemical Properties

Melting point	204 °C(dec.)
Boiling point	914.2±65.0 °C(Predicted)
Density	1.276±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
form	powder to crystal
pka	10.63±0.46(Predicted)
color	White to Almost white
CAS DataBase Reference	159858-22-7

Safety

HS Code

2924.29.7790

FMoc-Val-Cit-PAB Price

Product number	Packaging	Price	Product description	Buy
TCI Chemical F1223	25MG	$16	Fmoc-Val-Cit-PAB-OH	Buy
TCI Chemical F1223	100MG	$39	Fmoc-Val-Cit-PAB-OH	Buy
AK Scientific 2998DP	25mg	$259	Fmoc-Val-Cit-PAB	Buy
ChemScene CS-5170	250mg	$300	Fmoc-Val-Cit-PAB 97.15%	Buy
Iris Biotech GmbH ADC1030	250mg	$303.75	Fmoc-Val-Cit-PAB	Buy

More Price(18)

FMoc-Val-Cit-PAB Chemical Properties,Usage,Production

Uses

Fmoc-Val-Cit-PAB is a commonly used bridge for a degradable antibody-conjugated drug (ADC).

Description

Fmoc-Val-Cit-PAB-OH is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. Fmoc can be deprotected under basic condition.

FMoc-Val-Cit-PAB synthesis

159858-21-6

623-04-1

159858-22-7

Preparation Products And Raw materials

Raw materials

Carbamic acid, N-[(1S)-4-[(aminocarbonyl)amino]-1-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]butyl]-, 1,1-dimethylethyl ester
N5-(aminocarbonyl)-N2-[(phenylmethoxy)carbonyl]-L-ornithine
4-Aminobenzyl alcohol
H-Cit-PABA
Fmoc-Cit-PABA

FMOC-L-Valine
L-Citrulline
Fmoc-Val-Cit-OH
FMOC-VAL-OSU
9-Fluorenylmethyl chloroformate

1of2

Preparation Products

MC-Val-Cit-PAB
FMoc-Val-Cit-PAB-PNP
Mc-Val-Cit-PABC-PNP

FMoc-Val-Cit-PAB Supplier

Global(222)Suppliers

Region

Americas 1 China 208 Europe 1 India 4 Japan 1 United States 7

Clear All Done

Supplier	Tel	Email	Country	ProdList	Advantage
Chemtour Biotech Co., Ltd	+8617327281506	market@chemtour.com	China	1460	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9151	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10311	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Jurong Coupling Biotechnology Co., Ltd.	13656108824	coupling278191416@hotmail.com	CHINA	184	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58

FMoc-Val-Cit-PAB: Applications of FMoc-Val-Cit-PAB in Antibody-Drug Conjugates and Its Synthesis Method
FMoc-Val-Cit-PAB is a peptide conjugate with Val-Cit linker and PAB moiety, enhancing ADC stability and cytotoxicity in targeted drug delivery, especially in cancer therapy.
Apr 22，2024

FMoc-Val-Cit-PAB——Storage and operation

The molecular formula of Fmoc-Val-Cit-PAB is C33H39N5O6, and the exact molecular weight is 601.6692668199539. Its Catalog No. is HY-19318 and CAS No. is 159858-22-7.

Feb 25，2020