Description
Fmoc-N-amido-PEG4-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties
Yellow oil
Uses
Fmoc-NH-PEG4-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG4-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Application
Fmoc-NH-PEG4-CH₂CH₂COOH (CAS 557756-85-1) is a high-purity (＞98%) hetero-bifunctional PEG linker. Its synonyms include Fmoc-N-amido-PEG4-acid, Fmoc-PEG4-propionic acid and 4-propionic acid. This substance can be used in drug delivery systems, hydrogel systems, and the synthesis of ADCs and PROTACs, amongst other applications.
reaction suitability
reaction type: Pegylations
reagent type: cross-linking reagent
IC 50
Cleavable Linker; PEGs
References
[1] Cai P, et al. Synthesis of C3-Alkylated Indoles on DNA via Indolyl Alcohol Formation Followed by Metal-FreeTransfer Hydrogenation. Org Lett. 2019 Aug 14. DOI:
10.1021/acs.orglett.9b02132
