Description
D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals.1,2,3 Ins(1,2,3,5)P4 exhibits relatively weak agonist activity at the Ins(1,4,5)P3 receptor expressed in CHO cells, where it induces Ca2+ mobilization with an ED50 value of 93.3 µM, making it nearly 1,000-fold less effective than Ins(1,4,5)P3 in the same assay.4WARNING This product is not for human or veterinary use.
References
[1] BERRIDGE M J. Inositol trisphosphate and calcium signalling[J]. Nature, 1993, 361 6410: 315-325. DOI:
10.1038/361315a0[2] MAJERUS P W. Inositol phosphate biochemistry.[J]. Annual review of biochemistry, 1992, 61: 225-250. DOI:
10.1146/annurev.bi.61.070192.001301[3] SHEARS S B. The versatility of inositol phosphates as cellular signals[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 1998, 1436 1: Pages 49-67. DOI:
10.1016/s0005-2760(98)00131-3[4] NEIL T. BURFORD . Binding and activity of the nine possible regioisomers of myo-inositol tetrakisphosphate at the inositol 1,4,5-trisphosphate receptor[J]. Cell calcium, 1997, 21 4: Pages 301-310. DOI:
10.1016/s0143-4160(97)90118-4
