7-Chloro-5-(4-hydroxyphenyl)-1-methyl-3-(2-naphthylmethyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Uses

Bz-?423 is a 1,?4-?benzodiazepine that suppresses disease in lupus-?prone mice by selectively killing pathogenic lymphocytes.

Biological Activity

Bz-423 is an inhibitor of mitochondrial F1F0 ATP synthase. It binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPase, resulting in superoxide generation and apoptosis. BZ-423 was shown to block multidrug-resistant melanoma cells. In another study, Bz-423 selectively increased superoxide and induced the apoptosis of alloreactive T cells, which arrested established Graft versus Host Disease.', 'Bz-423 stimulates mitochondrial inner membrane pore (MIMP) opening in isolated mitochondria.

storage

Store at +4°C