216691-95-1

Bz-?423 is a 1,?4-?benzodiazepine that suppresses disease in lupus-?prone mice by selectively killing pathogenic lymphocytes.

Bz-423 is an inhibitor of mitochondrial F1F0 ATP synthase. It binds the oligomycin sensitivity conferring protein (OSCP) component of mitochondrial F1F0-ATPaseresulting in superoxide generation and apoptosis. BZ-423 was shown to block multidrug-resistant melanoma cells. In another studyBz-423 selectively increased superoxide and induced the apoptosis of alloreactive T cellswhich arrested established Graft versus Host Disease.''Bz-423 stimulates mitochondrial inner membrane pore (MIMP) opening in isolated mitochondria.

Bax; Bak

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