Preparation
First, cefepime and N-trimethylsilylacetamide were added to dichloromethane for 0.5 h. Subsequently, triethylamine dissolved in dichloromethane was added to the reaction system between 2-5 °C. Adjust the temperature to 2-5 °C and react for 24 h. After adding water, the aqueous layer was separated, and the aqueous phase was washed with methylene chloride. Wait for the solution to cool to 2-5 °C and adjust the pH=3 with sulfuric acid. Stir the resulting slurry for 2h. Filter to collect the solids and wash with water, adjust the pH=7.5-8.0 with sodium bicarbonate aqueous solution, add carbon, and stir for 30 min. Filter the mixture to collect the filtrate and adjust pH=3 with sulfuric acid. Finally, the solids are filtered and collected, and product Δ2-Cefepime is obtained by washing and drying.
