Chemical Properties
White to off-white powder
Uses
Reactant for:• ;Suzuki couplings1,2• ;Copper catalyzed arylation3
Uses
5-Fluoro-2-methoxyphenylboronic Acid is an important building blocks in organic syntheses. A reagent for Suzuki coupling reactions and copper catalyzed arylation reactions. A bacterial mutagen.
Synthesis
There are two main methods to synthesize 5-fluoro-2-methoxyphenylboronic acid: 1) Reacting with p-fluoroanisole and n-butyllithium solution dissolved in THF at -60 .
, then react with triisopropyl borate at -70 and then acidify with hydrochloric acid to obtain; 2) Use 2-bromo-4-fluoroanisole and n-butyllithium solution dissolved in THF first.
2) obtained by reacting 2-bromo-4-fluoroanisole with n-butyllithium solution dissolved in THF at -78 , then reacting with trimethyl borate at room temperature, then acidified with hydrochloric acid and washed with ammonium chloride solution.
