ChemicalBook CAS DataBase List 4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide

Product Name4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide
CAS36707-00-3
CBNumberCB02264862
MFC13H15N5O6
MW337.29
MOL File36707-00-3.mol
MSDS FileSDS

Chemical Properties

storage temp.	Store at RT
solubility	DMF: slightly soluble; DMSO: 2 mg/ml
form	powder
color	white to beige
InChI	1S/C13H15N5O6/c14-10-6-7(20)4(11(15)23)1-18(12(6)17-3-16-10)13-9(22)8(21)5(2-19)24-13/h1,3,5,8-9,13,19,21-22H,2H2,(H2,15,23)(H2,14,16,17)/t5-,8-,9-,13-/m1/s1
InChIKey	SPBWHPXCWJLQRU-FITJORAGSA-N
SMILES	O=C1C(C(N)=O)=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=C1C(N)=NC=N3
FDA UNII	W3UEK36Q7X
UNSPSC Code	12352200
NACRES	NA.77

Safety

Symbol(GHS)

Signal word

Danger

Hazard statements

H301

Precautionary statements

P301+P310+P330

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

WGK 3

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral

NFPA 704:

	0
2		0

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Price

Product number	Packaging	Price	Product description	Buy
Sigma-Aldrich SML1342	5mg	$149	API-1	Buy
Sigma-Aldrich SML1342	25mg	$552	API-1	Buy
Cayman Chemical 22081	1mg	$38	API-1 ≥98%	Buy
Cayman Chemical 22081	5mg	$168	API-1 ≥98%	Buy
Cayman Chemical 22081	10mg	$297	API-1 ≥98%	Buy

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Chemical Properties,Usage,Production

Uses

NSC 177223 is a Akt/protein kinase B inhibitor. It binds to pleckstrin homologous domain of Akt and blocks Akt membrane translocation. Treatment of cancer cells with NSC 177223 results in inhibition of the kinase activities and induction of cell growth arrest and apoptosis selectively in human cancer cells that harbor constitutively activated Akt.

Biological Activity

API-1 is a potent and specific Akt/PKB inhibitor. API-1 binds to pleckstrin homology (PH) domain of Akt and blocks Akt membrane translocation. The compound inhibits all three members of the family Akt1/PKBa, Akt2/PKBb and Akt3/PKBg. API-1 does not inhibit the activation of PKC, SGK, PKA, STAT3, Erk-1/2 or JNK.

in vivo

API-1 (10 mg/kg; i.p.; daily for 6-8 weeks) selectively inhibits the growth of tumors with hyperactivated Akt in OVCAR3 and PANC-1 xenograft mice model^[3].

Animal Model:	8-week-old female nude mice (implanted tumors with hyperactivated Akt (OVCAR3 and PANC-1) into the left flank and those tumors that express low levels of activated Akt (OVCAR5 and COLO357) into the right flank)^[3]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection (i.p.); daily for 6-8 weeks
Result:	Inhibited OVCAR3 and PANC1 tumor growth by 70 and 50%, respectively. Had little effect on the growth of OVCAR5 and COLO357 cells in nude mice. Had no effects on blood glucose level, body weight, activity, and food intake of mice. Phosphorylation levels of Akt were reduced about 70% without a change of total Akt content.

IC 50

Caspase-8; Caspase 3; Caspase-9; PARP

storage

Store at RT

Preparation Products And Raw materials

4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30225	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
NANJING YINGWEN BIOTECHNOLOGY CO LTD	+8613382787392	sales@aeechem.com	China	10001	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

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4-Amino-5,6,7,8-tetrahydro-5-oxo-8-(β-D-ribofuranosyl)pyrido[2,3-d]pyrimidine-6-carboxamide Spectrum

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