Uses
Mastoparan-7 has been used to study mastoparan-stimulated nucleotide binding to G proteins.
General Description
Mastoparan-7 is an analog of the mastoparan peptide. It is present in the venom of
Vespula lewisii. It was originally isolated from wasp venom.
Biochem/physiol Actions
Mastoparan-7 (Mas-7) stimulates the G protein subunit Gαo/i by its mode of action (to bind to the plasma membrane). It possesses antiviral activity and is associated with histamine release from mast cells. It is also involved in the induction of potent mitochondrial permeability and tumor cell cytotoxicity.
