Chemical Properties
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Tripterygium wilfordii.
Uses
Triptonide is a Triptolide (T815600) analogue used in the preparation of cytotoxic fluorinated Triptolide.
Definition
ChEBI: Triptonide is a diterpene triepoxide that is triptobenzene K in which the acylhydroquinone moiety has undergone oxidation to the corresponding triepoxyketone derivative. It has been isolated from the roots of Tripterygium wilfordii. It has a role as an antineoplastic agent, an anti-inflammatory agent and an immunosuppressive agent. It is a cyclic ketone, an organic heteroheptacyclic compound, a diterpene triepoxide and a butenolide.
in vivo
Triptonide (5 mg/kg; i.p.; daily; for 34 days) exerts a strong anti-lymphoma effect in mice[2].
| Animal Model: | Eight-week-old female NOD/SCID mice (18-22 g), with 3 x 107 Raji cells xenograft[2] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneal injection, daily, for 34 days |
| Result: | Potently inhibited lymphoma cell growth and tumorigenic capability. |
target
ERK | IL Receptor | GSK-3 | p38MAPK | Wnt/β-catenin
