Synthesis
2,4,5-Trimethoxy acetophenone is synthesised using 2-Hydroxy-4,5-dimethoxy acetophenone as raw material by chemical reaction. The specific synthesis steps are as follows:
2-Hydroxy-4,5-dimethoxyacetophenone(5 g,0.0255 mole)
in dry acetone (100 ml)is refluxed for 30 hr under anhydrous conditions
with dimethyl sulphate (2.8 ml,3.78 g,0.03 mole)and ignited potassium
carbonate (20 g).The mixture is filtered and the inorganic residue washed
with hot acetone (2 x 20 ml).The combined acetone solution is distilled
and the oily residue macerated with crushed ice.The solid product is
filtered,washed with water and dried.It is crystallised from benzene as
colourless needles.Yield 4.5g (84.1%).M.p.97(lit.m.p.102).
