clitocine
- Product Nameclitocine
- CAS105798-74-1
- CBNumberCB01359969
- MFC9H13N5O6
- MW287.231
- MDL NumberMFCD00875657
- MOL File105798-74-1.mol
- MSDS FileSDS
clitocine Chemical Properties,Usage,Production
Definition
ChEBI: Clitocine is a N-glycosyl compound.Biological Activity
Clitocine, an adenosine nucleoside analog derived from mushrooms, is a potent readthrough. As an inhibitor of nonsense mutations, it can induce the production of p53 protein in cells carrying p53 nonsense mutant alleles. It induces apoptosis in multidrug-resistant tumor cells by targeting Mcl-1. Has anticancer activity.in vitro
Clitocine incorporation into mRNA is required for premature stop codon readthrough activity, and the presence of clitocine at the third position of a premature stop codon is sufficient to promote robust readthrough.
Clitocine (0-0.8 μM ; 24 hours) enhances TRAIL-lethality in in LS411N and SW620 cells. It (0.2μM; 36 hours) significantly potentiates TRAIL-mediated apoptosis.
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in vivo
Citocine (0.3-3 mg/kg; sc; five times per week)-induced p53 inhibits CAOV-33 p53-UAA136 tumor growth in a xenograft model.
| nu/nu mice (CAOV-3p53-UAA136 xenograft tumors) | |
| Dosage: | 0.3, 3 mg/kg (or 20 mg/kg once per week) |
| Administration: | Sc; five times per week |
| Result: | CAOV-33 p53-UAA136 tumor growth was inhibited. |
Preparation Products And Raw materials
clitocine Suppliers
Global(21)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 | |
| +86-0571-86912261 +8613735419629 |
sales@newcanbio.com | China | 9980 | 58 | |
| support@targetmol.com | United States | 38631 | 58 | ||
| +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 | |
| +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 | |
| +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 | |
| 571-89925085 | sales@amadischem.com | China | 131957 | 58 | |
| +86-023-62871537 | sales@rosewachem.com | China | 2827 | 58 | |
| +86057186818502 13588463833 |
info@sagechem.com | China | 10266 | 58 | |
| 86-574-27787657 | info@dearchem.com | China | 4613 | 58 |
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