Uses
[Glu^1] Fibrinopeptide B is used as a indicator of coagulation and fibrinolytic activity. And is useful for the tuning and calibration of electrospray ionization and MALDI mass spectrometers.
General Description
Fibrinopeptide B (FPB) is produced during the cleavage of fibrinogen, by thrombin, to fibrin monomer. It is cleaved off from the N-terminal of the fibrinogen β chain. This peptide is composed of 14 amino acids.
Biochem/physiol Actions
Fibrin formation is an essential part in wound healing and inflammation. Fibrinopeptide B (FPB) can also cause chemotactic migration of neutrophils, without the simultaneous release of lysosome enzymes. It is produced during the coagulation of fibrinogen, which is essential for physiological homeostasis. It is involved in various disorders such as thrombosis and disseminated intravascular coagulation.
