cerebrolysin

Pharmacological Study

Cerebrolysin is a peptidergic drug produced from purified porcine brain proteins, with postulated neurotrophic and neuroprotective effects (Windisch et al., 1998; Rockenstein et al., 2003; Plosker and Gauthier, 2009; Gauthier et al., 2015). A small open-label trial in patients with AD and VaD (Rainer et al., 1997) showed minimal improvement in cognitive tests and clinical global impression. The main side effects were nausea and vertigo. A Cochrane review (Chen et al., 2013) of six RCTs with a total of 597 participants showed minimal MMSE and ADAS-cog improvements.