Synthesis
The general procedure for synthesizing 2-bromo-4-trifluoromethylphenol from p-trifluoromethylphenol is as follows: 32 g of p-trifluoromethylphenol was dissolved in 200 mL of dichloromethane. An equimolar amount of bromine was slowly added dropwise under cooling conditions, and the dropwise process lasted about 2 hours. After the dropwise addition was completed, the reaction mixture was continued to be stirred at room temperature for 12 hours. Upon completion of the reaction, the reaction system was washed with saturated sodium bicarbonate solution to neutral. Subsequently, the organic phase was dried and the solvent was removed by distillation to give 40 g of a thick liquid product. This thick liquid is the target compound 2-bromo-4-trifluoromethylphenol.
References
[1] Tetrahedron, 2003, vol. 59, # 34, p. 6545 - 6558
[2] Patent: WO2009/89192, 2009, A1. Location in patent: Page/Page column 30-31
[3] Chemistry - A European Journal, 2012, vol. 18, # 11, p. 3286 - 3291
[4] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 4, p. 734 - 745
[5] Tetrahedron Letters, 2001, vol. 42, # 45, p. 8093 - 8096
