Uses
Autophagy-IN-2 (Compound 7h) is an autophagic flux inhibitor. Autophagy-IN-2 induces cancer cell apoptosis and can be used for triple-negative breast cancer research[1].
in vivo
Autophagy-IN-2 (Compound 7h) (5 and 15 mg/kg; i.p.; every 3 days for 3 weeks) suppresses tumor growth in a dose-dependent manner[1].
| Animal Model: | Six-week-old female NOD/SCID mice, MDA-MB-231 xenograft[1] |
| Dosage: | 5 mg/kg, 15 mg/kg |
| Administration: | Intraperitoneal injection, every 3 days for 3 weeks |
| Result: | Suppressed human TNBC tumor growth in a dose-dependent manner and resulted in a concentration-dependent upregulation of LC3B-II, p62, γH2AX and PARP. |
References
[1] Yang DL, et al. Discovery of fused benzimidazole-imidazole autophagic flux inhibitors for treatment of triple-negative breast cancer. Eur J Med Chem. 2022 Jun 26;240:114565. DOI:
10.1016/j.ejmech.2022.114565
