Description
Ac-LEVD-CHO is a caspase-4 inhibitor.1 It inhibits IL-1α expression and secretion and caspase-4 activation induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts when used at a concentration of 30 μM. Ac-LEVD-CHO (10 μM) also reduces apoptosis induced by expression of the dominant negative adenoviral RNA-dependent protein kinase (Ad-Δ6PKR) in A549 and PC3 cancer cells.2WARNING This product is not for human or veterinary use.
References
[1] HYE-KYOUNG JUN. Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts[J]. Cell Death and Differentiation, 2017, 25 2: 380-391. DOI:
10.1038/cdd.2017.167[2] ABUJIANG PATAER. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.[J]. Cancer Biology & Therapy, 2009, 8 3: 245-252. DOI:
10.4161/cbt.8.3.7386
