Description
2-(Aminomethyl)-5-methylpyrazine can be used as a pharmaceutical synthesis intermediate, for example, to prepare pyrocatecholamide, which is an antiplatelet drug with a dual inhibitory action. This substance can be prepared from 2,5-dimethylpyrazine as a reaction raw material.
Synthesis
2,5-dimethylpyrazine can be used as a reaction raw material to prepare the intermediate 2-chloromethyl-5-methylpyrazine. It can then be further reacted with sodium iodide and potassium phthalimide to prepare N-((5-methylpyrazine-2-yl)methyl)isoindole-1,3-dione. Finally, it can be reacted with hydrazine hydrate to prepare 2-(Aminomethyl)-5-methylpyrazine.
