Synthesis
General procedure for the synthesis of 3-amino-4-methylacetophenone from 3-nitro-4-methylacetophenone: 5% palladium-carbon catalyst (wet state, 100 mg) was added to a solution of ethanol (12 mL) containing 3-nitro-4-methylacetophenone (0.4 g, 2.23 mmol). The reaction flask was evacuated and displaced with hydrogen (repeated three times). After stirring the reaction mixture under hydrogen atmosphere for 3 hours, the catalyst was removed by filtration and the filtrate was concentrated to give 3-amino-4-methylacetophenone (330 mg, 99% yield).
References
[1] Patent: WO2003/90912, 2003, A1. Location in patent: Page/Page column 129
[2] Helvetica Chimica Acta, 2010, vol. 93, # 7, p. 1261 - 1273
[3] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 8, p. 854 - 859
[4] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 7, p. 798 - 803
[5] Patent: CN105481790, 2016, A. Location in patent: Paragraph 0130; 0131; 0132; 0133
