cyamemazine Struktur

Cyamemazin

Bezeichnung:Cyamemazin

CAS-Nr3546-03-0

Englisch Name:cyamemazine

CBNumberCB9914843

SummenformelC19H21N3S

Molgewicht323.46

MOL-Datei3546-03-0.mol

Synonyma

Cyamemazin

Cyamemazin physikalisch-chemischer Eigenschaften

Schmelzpunkt	90-95°C
Siedepunkt	bp0.2-0.5 205-220°
Dichte	1.21±0.1 g/cm3(Predicted)
storage temp.	Refrigerator
Löslichkeit	DMSO: ≥5mg/mL
pka	9.31±0.28(Predicted)
Aggregatzustand	powder
Farbe	light yellow to yellow-green

Sicherheit

Kennzeichnung gefährlicher	Xi,N
R-Sätze:	50
S-Sätze:	61
RIDADR	UN 3077 9 / PGIII
WGK Germany	3
Toxizität	LDLo oral in man: 107mg/kg

Gefahreninformationscode (GHS)

cyamemazine Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Greenish Yellow Solid
Originator
Terckian,Theraplix,France,1972
Verwenden
Cyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.
Definition
ChEBI: Cyamemazine is a member of phenothiazines.
Manufacturing Process
The following is taken from US Patent 3,057,851. Milorganite was extracted with water to obtain an aqueous extract containing vitamin B12 active substances. This aqueous extract was purified by treatment with an ion exchange resin according to the following method. An aqueous extract of milorganite, 100 ml containing 300 μg of vitamin B12 active substances and 4.5 grams of total solids, was combined with 0.5 gram of sodium nitrite and 0.4 gram of potassium cyanide. The resulting solution was adjusted to pH 4.0 with hydrochloric acid and heated to boiling. The boiled solution was filtered through a Super-Cel filter surface, and the filter was then washed with water. The filtrate was obtained in a total volume of 130 ml including the washings.
Amerlite XE-97, an ion exchange resin of the carboxyl type (Rohm and Haas), was classified to an average wet particle size of 100 to 150 mesh. The classified resin was utilized in the hydrogen form, and was not buffered during the ion exchange fractionation. The classified resin, in the amount of 35 ml, was packed into a glass column having a diameter of 25 mm and a height of 250 mm. The cyanide-treated aqueous extract of milorganite was infused gravitationally into the ion exchange bed at a rate of 3 ml per minute.
The effluent was discarded and the resin bed was then washed with the following solutions in the specified sequence: (1) 120 ml of an aqueous 0.1 N hydrochloric acid solution; (2) 75 ml of an aqueous 85% acetone solution; and (3) 70 ml of an aqueous 0.1 N hydrochloric acid solution. After washing, the resin bed was eluted with an aqueous 60% dioxane solution containing 0.1 N of hydrochloric acid. In this elution, 8 ml of colored eluate was collected. This portion of the eluate was found to contain 295 μg of cyanocobalamin and 9 mg of total solids.
Therapeutic Function
Tranquilizer

cyamemazine Upstream-Materialien And Downstream Produkte

Cyamemazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3546-03-0, cyamemazine Verwandte Suche:

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