N-2-(4-bromobenzhydryloxy)ethyldimethylamine

N-2-(4-bromobenzhydryloxy)ethyldimethylamine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Bromazine,Shanghai Lansheng Corporation

• Verwenden

  Antihistaminic.

• Definition

  ChEBI: A tertiary amino compound that is the 4-bromobenzhydryl ether of 2-(dimethylamino)ethanol. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies.

• Manufacturing Process

  28.1 parts of p-bromobenzhydrylbromide are heated to boiling, under reflux and with stirring, with 50 parts of ethylene chlorohydrin and 5.3 parts of calcined sodium carbonate. The reaction product is extracted with ether and the etheral solution washed with water and dilute hydrochloric acid. The residue from the solution in ether [p-bromobenzhydryl(β-chloroethyl)ether].
  28.1 parts of this ether are heated with 12 parts of dimethylethylamine in a sealed tube for 4 hours at 110°C. The product of the reaction is extracted several time with dilute hydrochloric acid. The acid solution made alkaline, in the cold, with concentrated caustic soda solution, and the base which separates taken up in ether. The ether extract is washed with concentrated potassium carbonate solution, evaporated down, and the residue distilled in vacuo. Boiling point of p-bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine 151-154°C under 0.3 mm.
  p-Bromo-α-phenylbenzyloxy)-N,N-dimethylethylamine may be used as a hydrochloride.

• Trademarks

  Ambodryl.

• Therapeutic Function

  Antihistaminic

N-2-(4-bromobenzhydryloxy)ethyldimethylamine Upstream-Materialien And Downstream Produkte

N-2-(4-bromobenzhydryloxy)ethyldimethylamine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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