1-[(AMMONIOOXY)METHYL]-4-CHLOROBENZENE CHLORIDE

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P271：Nur im Freien oder in gut belüfteten Räumen verwenden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P363：Kontaminierte Kleidung vor erneutem Tragen waschen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

1-[(AMMONIOOXY)METHYL]-4-CHLOROBENZENE CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

• S-Sätze Betriebsanweisung:

  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
  S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

• synthetische

  To a solution of 83.7 gm (1.5 moles) of potassium hydroxide in 560 ml of water is added in turn with stirring, 300 gm (0.985 mole) of dipotassium hydroxylaminedisulfonate and 161 gm (1.0 mole) of 4-chlorobenzyl chlo­ride. The stirred mixture is heated on a steam bath for 1.75 hr. After cool­ing, the precipitate is filtered off and refluxed for 3 hr in 1000 ml of 1.5 Ν sulfuric acid. The reaction mixture is then cooled and made strongly alkaline with a 15% aqueous sodium hydroxide solution. The mixture is then extracted with ether repeatedly. The ether extracts are combined and evaporated to dryness. The solid residue (crude free base, 80 gm, i.e., 51.5% of theory, m.p. 35-38°C) is taken up in 1 liter of ether. Anhydrous hydrogen chloride is bubbled through this solution to precipitate the hy­drochloride salt. The yield is 59 gm (31%, overall), m.p. 243-244°C (dec); the free base has b.p. 100°C/1 mm Hg. In this preparation, the hydrolysis of the alkylated dipotassium hydroxyl­aminedisulfonate with only 1 liter of 1.5 Ν sulfuric acid seems somewhat skimpy. We suggest that a higher level of sulfuric acid be considered at that stage of the reaction, if the alkylation has indeed gone to completion. Once the O-alkylhydroxylamine has been prepared by this reaction, it may be N-alkylated to produce an N,Ο-dialkylhydroxylamine.
  The preparation of O-phenylhydroxylamine has been a synthetic chal­lenge for some time since it is quite unstable. Using hydroxylamine-O-sulfonic acid. A small quantity of this compound has been prepared [36]. Reaction conditions probably require further study to improve the yield. Extension of the reaction to the preparation of O-alkylhydroxylamines would be of interest.

1-[(AMMONIOOXY)METHYL]-4-CHLOROBENZENE CHLORIDE Upstream-Materialien And Downstream Produkte

1-[(AMMONIOOXY)METHYL]-4-CHLOROBENZENE CHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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