AROTINOLOL HCL

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

• Sicherheit

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P310：BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P321：Besondere Behandlung

  P330：Mund ausspülen.

  P405：Unter Verschluss aufbewahren.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

AROTINOLOL HCL Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Arotinolol hydrochloride i s a β-adrenergic blocker with weak α-antagonistic properties, useful in the treatment of hypertension.

• Originator

  Sumitomo (Japan)

• Verwenden

  Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.

• Definition

  ChEBI: Arotinolol hydrochloride is an aromatic amide and a member of thiophenes.

• Manufacturing Process

  To a solution of 2-mercapto-4-(5'-carbamoyl-2'-thiophenyl)thiazole, 3.2 g in 20 ml of 0.3 % aqueous sodium hydroxide solution, 1-chloro-3-tbutylaminopropanol, 12.64 g in 20 ml of methanol was added, while the temperature was maintained at 20°C.
  The reaction solution was stirred at room temperature for 4 h, and then condensed to a half volume in vacuo. The residual solution, added with 100 ml of water, was extracted with chloroform. The chloroform extract was washed with water, dried over anhydrous magnesium sulfate and evaporated in vacuo to give 4.8 g of 2-(3'-t-butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'- thiophenyl)thiazole, as crystals, melting point 234°-235.5°C (dec., recrystallized from methanol/water).
  In practice it is usually used as hydrochloride.

• Trademarks

  ALMARL

• Therapeutic Function

  Beta-adrenergic blocker

AROTINOLOL HCL Upstream-Materialien And Downstream Produkte

AROTINOLOL HCL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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