WITHAFERIN A

Bezeichnung:WITHAFERIN A

CAS-Nr5119-48-2

Englisch Name:WITHAFERIN A

CBNumberCB9454365

SummenformelC28H38O6

Molgewicht470.6

MOL-Datei5119-48-2.mol

WITHAFERIN A physikalisch-chemischer Eigenschaften

Schmelzpunkt	252-253℃
alpha	D28 +125° (c = 1.30 in CHCl3)
Siedepunkt	680.7±55.0 °C(Predicted)
Dichte	1.28
Flammpunkt	226℃
storage temp.	Desiccate at -20°C
Löslichkeit	Soluble in DMSO (up to 20 mg/ml)
pka	13.49±0.70(Predicted)
Aggregatzustand	White solid
Farbe	White
Stabilität	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey	DBRXOUCRJQVYJQ-CKNDUULBSA-N

Sicherheit

Kennzeichnung gefährlicher	T
WGK Germany	3
RTECS-Nr.	KE7288500
HS Code	29322090

Gefahreninformationscode (GHS)

WITHAFERIN A Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Withaferin A (5119-48-2) displays potent antiangiogenesis activity inhibiting endothelial cell sprouting in vitro?(IC50?= 12 nM) and?in vivo.1?Potently inhibits NF-κB activation by preventing TNFα-induced activation of IKKβ.2?Covalently binds to the intermediate filament protein, vimentin3?inducing its disassembly and serine 56 phosphorylation4. Inhibits reactive gliosis and blocks TNFα-mediated neuronal apoptosis in?in vivo?models.5
Chemische Eigenschaften
Solid
Verwenden
Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Withaferin A has recently been found to be a leptin sensitizer that can reduce the weight in obese mice fed in a high-fat diet (see C249500).
Definition
ChEBI: A withanolide that is 5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione substituted by hydroxy groups at positions 4 and 27 (the 4beta,5beta,6beta,22R stereoisomer). Isolated from Phys lis longifolia, it exhibits cytotoxic activity.
Biologische Aktivität
Steroid lactone that displays anti-inflammatory, antitumor and antiangiogenic activity. Inhibits endothelial cells (HUVEC) spouting in vitro (IC 50 = 12 nM) and in vivo . Prevents NF- κ B activation by inhibiting activation of IKK β . Also inhibits chymotrypsin-like activity of the 20S proteasome.
target
ROS | NF-kB | p53 | STAT | PARP | Bcl-2/Bax | Caspase | TGF-β/Smad | TNF-α | COX | PGE | PI3K | Akt | JNK | p38MAPK
Lager
Store at -20°C
Einzelnachweise
1) Mohan?et al.?(2004),?Withaferin A is a potent inhibitor of angiogenesis; Angiogenesis, 7 115 2) Kaileh?et al.?(2007),?Withaferin A strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with inhibition of its kinase activity; J. Biol. Chem.,?282?4253 3) Bargagna-Mohan?et al.?(2007),?The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin; Chem. Biol.,?14?623 4) Thaiparambil?et al.?(2011),?Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation; Int. J. Cancer,?129?2744 5) Livne-Bar?et al.?(2016),?Pharmacologic inhibition of reactive gliosis blocks TNF-α-mediated neuronal apoptosis;?Cell Death Dis.,?7?e2386

WITHAFERIN A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5119-48-2, WITHAFERIN A Verwandte Suche:

Send Inquriy