CATHEPSIN D Struktur

CATHEPSIN D

Bezeichnung:CATHEPSIN D

CAS-Nr9025-26-7

Englisch Name:CATHEPSIN D

CBNumberCB9265367

SummenformelNULL

Molgewicht0

MOL-DateiMol file

CATHEPSIN D physikalisch-chemischer Eigenschaften

storage temp.	-20°C
Aggregatzustand	lyophilized powder
Farbe	white
Biologische Quelle	human
Wasserlöslichkeit	Reconstitute in water at 1µg/µl
Specific Activity	≥250units/mg protein (E1%/280)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
F	10-21

CATHEPSIN D Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Cathepsin D, human liver is useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. It contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. It is a useful prognostic indicator for breast cancer.
Verwenden
Cathepsin D from human liver has been used:
- in β-secretase activity assay
- for enzymatic degradation of amyloid β 1-42
- in microinjection of human foreskin fibroblasts
Allgemeine Beschreibung
Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis.
Biochem/physiol Actions
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
läuterung methode
Cathepsin D is purified on a CM column after (NH4)2SO4 fractionation and dialysis, then starch-gel electrophoresis and by ultracentrifugal analysis. Finally chromatograph on a DEAE column [Press et al. Biochem J 74 501 1960].

CATHEPSIN D Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

9025-26-7, CATHEPSIN D Verwandte Suche:

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