Indole alkaloid

Indole alkaloid Chemische Eigenschaften,Einsatz,Produktion Methoden

• Definition

  ChEBI: Alstonine is an indole alkaloid with formula C21H20N2O3, isolated from several Rauvolfia species and exhibits antipsychotic activity. It has a role as an antipsychotic agent. It is a methyl ester, an organic heteropentacyclic compound, a zwitterion and an indole alkaloid. It is a conjugate base of an alstonine(1+).

• Biologische Aktivität

  Alstonine is the main indole alkaloid compound of a botanical drug. Alstonine has antipsychotic, anxiolytic, anticancer and antimalarial properties.

• in vitro

  Alstonine has the capacity to distinguish cancer DNA from healthy tissue DNA; it inhibits DNA in vitro synthesis when DNA from different cancerous tissues or cells is used as template. Practically without effects on DNA from healthy tissues.

• in vivo

  In mice models Alstonine shows a clear, dose-dependent, potent antipsychotic profile. Alstonine (ip) prevents amphetamine-induced lethality, with active doses within the range of 0.5-2.0 mg/kg.
  Alstonine (0.1, 0.5 and 1.0 mg/kg) prevents MK-801 induced hyperlocomotion. Because Alstonine partially reverses MK-801-induced increase in locomotion both at the hole-board and locomotor activity cages.
  Alstonine successfully treats a relatively important proportion of BALB/C mice inoculated with transplantable YC8 lymphoma ascites cells as well as Swiss mice bearing Ehrlich ascites carcinoma cells.

Indole alkaloid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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