6-METHOXY-2-NAPHTHYLACETIC ACID Struktur

6-Methoxynaphthalin-2-essigsure

Bezeichnung:6-Methoxynaphthalin-2-essigsure

CAS-Nr23981-47-7

Englisch Name:6-METHOXY-2-NAPHTHYLACETIC ACID

CBNumberCB9249046

SummenformelC13H12O3

Molgewicht216.23

MOL-Datei23981-47-7.mol

Synonyma

6-Methoxynaphthalin-2-essigsure

6-Methoxynaphthalin-2-essigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	170-172°C
Siedepunkt	408.8±20.0 °C(Predicted)
Dichte	1.235
RTECS-Nr.	QJ1045000
storage temp.	Sealed in dry,2-8°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
pka	4.35±0.30(Predicted)
Aggregatzustand	Off-white solid.
Farbe	Off-White to Yellow

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi,N
R-Sätze:	22-36/37/38-37/38-41-50
S-Sätze:	26-39-61
HS Code	2916399090

Gefahreninformationscode (GHS)

6-METHOXY-2-NAPHTHYLACETIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Yellow Solid
Verwenden
A metabolite of Nabumetone. A competitive, non-selective COX inhibitor.
Definition
ChEBI: (6-methoxy-2-naphthyl)acetic acid is a monocarboxylic acid consisting of 2-naphthylacetic acid having a methoxy substituent at the 6-position. The active metabolite of the prodrug nabumetone. It has a role as an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a drug metabolite and a xenobiotic metabolite. It is a monocarboxylic acid and a methoxynaphthalene. It is functionally related to a 2-naphthylacetic acid.
Biologische Aktivität
6-methoxy naphthalene acetic acid is a competitive and non-selective cox inhibitor with ki values of 21 and 19 μm for ovine cox-1 and -2, respectively [1][2][3].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].6-methoxy naphthalene acetic acid (6-mna) is a competitive and non-selective cox inhibitor with ki values of 21 and 19 μm for ovine cox-1 and -2, respectively [1][2]. 6-mna is a metabolite of nebumetome. 6-mna inhibited human recombinant cox-1 and -2 with ic50 values of 70 and 20 μm, respectively [1].
Einzelnachweise
[1]. barnett j, chow j, ives d, et al. purification, characterization and selective inhibition of human prostaglandin g/h synthase 1 and 2 expressed in the baculovirus system. biochim biophys acta. 1994 nov 16;1209(1):130-9.
[2]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[3]. laneuville o1, breuer dk, dewitt dl, et al. differential inhibition of human prostaglandin endoperoxide h synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. j pharmacol exp ther. 1994 nov;271(2):927-34.

6-Methoxynaphthalin-2-essigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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