n-Butyryl tri-n-hexyl citrate

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P273：Freisetzung in die Umwelt vermeiden.

  P391：Verschüttete Mengen aufnehmen.

  P501：Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

n-Butyryl tri-n-hexyl citrate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Trihexyl O-Butyrylcitrate is a non-toxic plasticizer, widely used in non-toxic PVC granulation, medical products, soft children's toys, ink coatings, etc.

• Application

  Trihexyl O-Butyrylcitrate can be used as an intermediate in pharmaceutical synthesis.

• Synthese

  Trihexyl O-Butyrylcitrate was prepared as follows: 1) To a 1 liter four-neck flask equipped with a stirrer, immersion thermometer, subsurface nitrogen sparge tube and Barrett trap with condenser 330 g n-hexanol, 180 g citric acid and 50 ml heptane. The reaction mass was heated to reflux (about 120°C) with a heating mantle and 1.5 grams of tetra-n-butyl titanate esterification catalyst was added. The reaction mass was esterified at 120-140°C until the acidity was less than 2 mgKOH/g acidity. The pressure was reduced to 20 mmHg using a vacuum pump to distill off excess n-hexanol and heptane azeotrope. The ester-containing reaction mass was then stripped with fresh steam at a temperature of 130-140° C. and full vacuum until no residual n-hexanol was detected by gas chromatography.
  2) The ester-containing reaction mass was cooled to 90°C, and 0.4 g of concentrated sulfuric acid was added dropwise with stirring. n-Butyric anhydride (166 g) was added dropwise with stirring, maintaining the acylation temperature between 90-110°C. The acylation reaction mixture was stirred and allowed to proceed for 2 hours to prepare the acylated ester. response quality. By-product butyric acid was removed by vacuum distillation at 110°C.

n-Butyryl tri-n-hexyl citrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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